HIV Cure Research
نویسندگان
چکیده
منابع مشابه
Controversies in HIV cure research
BACKGROUND Antiretroviral therapy significantly reduces HIV viral burden and prolongs life, but does not cure HIV infection. The major scientific barrier to a cure is thought to be the persistence of the virus in cellular and/or anatomical reservoirs. DISCUSSION Most efforts to date, including pharmaco, immuno or gene therapy, have failed to cure patients, with the notable exception of a stem...
متن کاملHIV cure research: a formidable challenge
The ultimate goal of HIV cure research is to allow HIV-infected individuals to be free of disease in the absence of antiretroviral therapy. We discuss current directions and future opportunities aimed at achieving sustained virological remission, and possibly eradication. A multidisciplinary approach to HIV cure research will be important, and ethical, social and behavioural research should be ...
متن کاملHIV cure research: expanding the ethical considerations.
Mounting evidence is fueling excitement over the possibility of curing HIV-infection. Two “Boston patients” who underwent bone marrow transplantation1 and a “Mississippi baby” who was given aggressive antiretroviral therapy (ART)2 soon after birth seem to be free of HIV-infection. These accounts build upon reports of the “Berlin patient” who lacks evidence of HIV-infection following transplanta...
متن کاملNonhuman Primate Models for HIV Cure Research
1 Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 2 Department of Microbiology and Molecular Genetics, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 3 Department of Pathology, School of Medicine, University of Pittsburgh, Pittsburgh, Pennsylvania, United States of America, 4 Department...
متن کاملAnimal models in HIV cure research
Current HIV antiretroviral therapy (ART) successfully inhibits viral replication in the majority of HIV-infected individuals. However, ART is not curative and lifelong adherence is required. Despite the undisputed benefit of ART, long-lived latently infected cells that carry HIV-integrated DNA remain. Hence, upon ART interruption, HIV-infected subjects experience viral rebound. Interestingly, s...
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ژورنال
عنوان ژورنال: Annals of Internal Medicine
سال: 2013
ISSN: 0003-4819
DOI: 10.7326/0003-4819-159-7-201310010-00694